loading

New Users

Create a free account to get started.

Required for CE

Returning Users

Take the Online Course

Free to Use
Start learning and review material anytime without having to register.

Sign In and Save Your Progress
Create an account, sign in, and track your progress as you work.

Free Continuing Education
Sign in and obtain free CME or CNE as you work through the modules.

Self-Study Modules and Sections

  1. In this 6-hour module, novice-to-expert health care professionals can develop proficiency in the fundamental skills needed to assess, initiate, and monitor HIV PrEP. Learners who complete all 5 lessons in this module may take the optional knowledge assessment test and earn an HIV PrEP Training Certificate.
  2. These 6 topics explore content addressed in the HIV PrEP Fundamentals module in more detail. The selected topics focus on populations where less HIV PrEP data exits, as well as considerations for same-day HIV PrEP and how to provide HIV PrEP in sexual health clinic settings.

Core Competencies for the National HIV PrEP Curriculum

The following is an outline and list of Core Competency Modules (with sub-competency lessons and learning objective performance indicators).

Module 1. HIV PrEP Fundamentals

Module Core Competency
Lessons
Learning Objective Performance Indicators
  • Define HIV PrEP and describe the potential role of HIV PrEP in reducing new HIV infections
  • State the HIV PrEP goal as described in the Ending the HIV Epidemic (EHE) initiative in the United States
  • Discuss the major studies demonstrating HIV PrEP efficacy and safety
  • Examine the barriers and disparities that impact HIV PrEP uptake
  • Summarize strategies to reduce stigma and barriers related to HIV PrEP access and usage
  • Discuss HIV PrEP with all sexually active adolescents and adults and persons who inject drugs
  • Summarize key epidemiology features of persons newly diagnosed with HIV in the United States
  • State the Ending HIV Epidemic initiative goals for reducing HIV infections in the United States by 2025 and 2030
  • Identify factors associated with sexual activity that may increase the risk of HIV acquisition
  • Summarize the CDC guideline recommendations for assessing HIV PrEP eligibility and initiation
  • List the three medications approved by the U.S. Food and Drug Administration (FDA) for HIV PrEP
  • Explain the indications, dosing, and formulations, for FDA-approved HIV PrEP medications
  • Discuss the issues and recommendations for HIV PrEP usage in persons with renal impairment
  • Describe on-demand (2-1-1) HIV PrEP
  • Summarize the multiple factors to consider when choosing HIV PrEP medications for selected patients
  • Provide a rationale for obtaining baseline laboratory studies prior to starting HIV PrEP
  • List the 2021 CDC recommendations for baseline laboratory tests prior to initiating HIV PrEP based on the specific HIV PrEP regimen to be prescribed
  • Summarize CDC recommendations for prescribing oral and injectable HIV PrEP, follow-up monitoring, and strategies for providing adherence support
  • Define and describe same-day HIV PrEP, including protocols and exclusions for initiating same-day HIV PrEP
  • Explore the concept of "time to protection" for oral and injectable HIV PrEP
  • Explain possible models of care for follow-up of persons receiving HIV PrEP
  • List recommended laboratory monitoring tests for persons receiving HIV PrEP
  • Summarize challenges in HIV diagnosis in persons receiving HIV PrEP
  • Describe the potential for HIV drug resistance in persons who are diagnosed with HIV after receiving HIV PrEP
  • Discuss appropriate management of persons who are newly diagnosed with HIV while taking HIV PrEP

Module 2. HIV PrEP In-Depth Topics

Module Core Competency
Lessons
Learning Objective Performance Indicators
  • Describe the intersection of sexual debut, substance use, and sexual activities that can increase risk of HIV acquisition for adolescents and young adults
  • Review HIV PrEP coverage among adolescents and young adults in the United States
  • Summarize the HIV and sexually transmitted infections epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in adolescents and young adults
  • Discuss the clinical management of HIV PrEP for adolescents and young adults, including obtaining a sexual history, choosing HIV PrEP medications, and laboratory monitoring
  • Cite the legal and insurance issues of providing HIV PrEP services to adolescents and young adults
  • Explain the interplay of the multiple factors and complex barriers that put transgender and gender-diverse people at high risk for HIV acquisition
  • Develop fluency in the use of evolving transgender concepts and terms
  • Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in transgender and gender-diverse people
  • Explore the definition and multiple domains of gender affirmation and the impact of gender-affirming hormone therapy on HIV PrEP medications
  • Discuss the clinical management of transgender and gender-diverse people on HIV PrEP including sexual history, evaluation, HIV PrEP medications, monitoring, and reducing barriers to adherence
  • Explain how structural and intimate partner violence impacts the risk for HIV acquisition among cisgender women and pregnant persons
  • Provide a rationale for prescribing HIV PrEP for cisgender women of childbearing age
  • Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in cisgender women and in pregnant people
  • Explore the risks and benefits of using HIV PrEP in pregnant persons during the periconception period, pregnancy, or with breastfeeding
  • Discuss the clinical management of HIV PrEP for cisgender women and pregnant persons including sexual history, baseline evaluation, HIV PrEP medications, follow-up monitoring, and adherence
  • Explain the risk factors and impact of the opioid epidemic that contribute to HIV acquisition among people who inject drugs (PWID) in the United States
  • Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in PWID
  • Discuss the clinical management of HIV PrEP for PWID including substance use screening, sexual history, baseline evaluation, PrEP medications, follow-up monitoring, and adherence
  • Describe the barriers to HIV PrEP uptake in PWID and the strategies to increase HIV PrEP uptake in PWID
  • Provide a rationale for additional services for PWID that address opioid use and mental health disorders, and prevent other viral and bacterial infectious diseases
  • Discuss the rationale for delivering same-day (rapid) start of oral HIV PrEP
  • Define the concepts and terms specific to same-day (rapid) and standard HIV PrEP
  • Summarize the descriptive studies on implementation and outcomes of same-day (rapid) oral HIV PrEP
  • Differentiate clinic settings best suited to provide same-day (rapid) oral HIV PrEP services
  • List the laboratory tests required prior to and the day of prescribing oral HIV PrEP 
  • Discuss the rationale for providing HIV PrEP services in sexual health clinics based on epidemiology, population served, and sexual health clinic attributes
  • Summarize the evidence for the successful integration of HIV PrEP in sexual health clinics, as well as logistical and financial considerations
  • Identify HIV PrEP eligibility criteria, screening tools, and partner notification services
  • Explain how to optimize HIV PrEP uptake and use via education, outreach, staffing, follow-up, ongoing care, program monitoring
  • Describe cost-saving programs for HIV PrEP integration, including 340B eligibility
Self Assessment
The National HIV PrEP Curriculum is supported by the Centers for Disease Control and Prevention (CDC) and the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $625,000 from CDC and $300,005 from HRSA with 0% financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by CDC, HRSA, HHS, or the U.S. Government. This project is led by the University of Washington Infectious Diseases Education & Assessment (IDEA) Program.

Since you've received 80% or better on this quiz, you may claim continuing education credit.

You seem to have a popup blocker enabled. If you want to skip this dialog please Always allow popup windows for the online course.