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- Module 2 Overview
HIV PrEP In-Depth Topics - 0%Lesson 1
HIV PrEP for Adolescents and Young AdultsActivities- 0%Lesson 2
HIV PrEP for Transgender and Gender-Diverse PeopleActivities- 0%Lesson 3
HIV PrEP for Cisgender Women and Pregnant PersonsActivities- 0%Lesson 4
HIV PrEP for People Who Inject DrugsQuick ReferenceHIV PrEP In-Depth Topics Overview
Module Core Competency
Target Audience
These 6 topics explore content addressed in the HIV PrEP Fundamentals module in more detail. The selected topics focus on populations where less HIV PrEP data exits, as well as considerations for same-day HIV PrEP and how to provide HIV PrEP in sexual health clinic settings.Editor
David H. Spach, MDDavid H. Spach, MD
Editor-in-Chief
Professor of Medicine
Division of Allergy & Infectious Diseases
University of WashingtonDisclosures: None1Lesson 1 HIV PrEP for Adolescents and Young Adults
- Learning Objectives
- Describe the intersection of sexual debut, substance use, and sexual activities that can increase risk of HIV acquisition for adolescents and young adults
- Review HIV PrEP coverage among adolescents and young adults in the United States
- Summarize the HIV and sexually transmitted infections epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in adolescents and young adults
- Discuss the clinical management of HIV PrEP for adolescents and young adults, including obtaining a sexual history, choosing HIV PrEP medications, and laboratory monitoring
- Cite the legal and insurance issues of providing HIV PrEP services to adolescents and young adults
- Quick ReferenceHIV PrEP for Adolescents and Young Adults Core Concepts
- Background and HIV PrEP Coverage in Youth
- Epidemiology of STIs and HIV in Youth
- Evidence for HIV PrEP in Youth
- Clinic Visits and Obtaining a Sexual History in Adolescents
- Assessing for HIV PrEP in Youth
- HIV PrEP Medications for Youth
- Baseline Laboratory Evaluation
- Medication Adherence
- Follow-Up and Laboratory Monitoring
- Legal and Insurance Issues
- Summary Points
2Lesson 2 HIV PrEP for Transgender and Gender-Diverse People
- Learning Objectives
- Explain the interplay of the multiple factors and complex barriers that put transgender and gender-diverse people at high risk for HIV acquisition
- Develop fluency in the use of evolving transgender concepts and terms
- Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in transgender and gender-diverse people
- Explore the definition and multiple domains of gender affirmation and the impact of gender-affirming hormone therapy on HIV PrEP medications
- Discuss the clinical management of transgender and gender-diverse people on HIV PrEP including sexual history, evaluation, HIV PrEP medications, monitoring, and reducing barriers to adherence
- Quick ReferenceHIV PrEP for Transgender and Gender-Diverse People Core Concepts
- Background
- Introduction to Transgender Terms Concepts and Terms
- Epidemiology of HIV Among Transgender and Gender-Diverse People
- HIV PrEP Data in Transgender and Gender-Diverse People
- Drug Interactions between HIV PrEP Medications and Gender-Affirming Hormones
- Obtaining a Sexual History with Transgender and Gender-Diverse People
- Indications for HIV PrEP with Transgender and Gender-Diverse People
- HIV PrEP Medication Options for Transgender and Gender-Diverse People
- Baseline and Follow-Up Laboratory Evaluation
- Time to Achieve Protection After Initiating PrEP
- Addressing Barriers to HIV PrEP for Transgender and Gender-Diverse People
- Overview and Resources
- Summary Points
3Lesson 3 HIV PrEP for Cisgender Women and Pregnant Persons
- Learning Objectives
- Explain how structural and intimate partner violence impacts the risk for HIV acquisition among cisgender women and pregnant persons
- Provide a rationale for prescribing HIV PrEP for cisgender women of childbearing age
- Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in cisgender women and in pregnant people
- Explore the risks and benefits of using HIV PrEP in pregnant persons during the periconception period, pregnancy, or with breastfeeding
- Discuss the clinical management of HIV PrEP for cisgender women and pregnant persons including sexual history, baseline evaluation, HIV PrEP medications, follow-up monitoring, and adherence
- Quick ReferenceHIV PrEP for Cisgender Women and Pregnant Persons Core Concepts
- Background
- Epidemiology of HIV in Cisgender Women
- Evidence for HIV PrEP in Cisgender Women
- Evidence for HIV PrEP in Pregnant People and During Breastfeeding
- HIV PrEP Indications for Cisgender Women and Pregnant People
- Recommended HIV PrEP Medication Options for Cisgender Women and Pregnant People
- Interaction of HIV PrEP Medications with Hormonal Contraception
- Baseline Laboratory Evaluation
- Time to Achieve Protection After Initiating PrEP
- Follow-Up and Laboratory Monitoring
- Summary Points
4Lesson 4 HIV PrEP for People Who Inject Drugs
- Learning Objectives
- Explain the risk factors and impact of the opioid epidemic that contribute to HIV acquisition among people who inject drugs (PWID) in the United States
- Summarize the HIV epidemiology, clinical trial evidence, and indications that support the use of HIV PrEP in PWID
- Discuss the clinical management of HIV PrEP for PWID including substance use screening, sexual history, baseline evaluation, PrEP medications, follow-up monitoring, and adherence
- Describe the barriers to HIV PrEP uptake in PWID and the strategies to increase HIV PrEP uptake in PWID
- Provide a rationale for additional services for PWID that address opioid use and mental health disorders, and prevent other viral and bacterial infectious diseases
- Quick ReferenceHIV PrEP for People Who Inject Drugs Core Concepts
- Background
- Epidemiology of HIV among PWID
- Factors Associated with Increased Risk for HIV Among PWID
- Evidence for HIV PrEP Among PWID
- Assessing Indications for HIV PrEP Among PWID
- Recommended HIV PrEP Medications for PWID
- Baseline Laboratory Evaluation
- Time to Achieve Protection
- Follow-Up and Laboratory Monitoring
- Implementation of HIV PrEP for PWID
- Additional Care Services for PWID
- Summary Points
- Activity 4B.PrEP Options for PWID
5Lesson 5 Same Day (Rapid) Start for Oral HIV PrEP
- Learning Objectives
- Discuss the rationale for delivering same-day (rapid) start of oral HIV PrEP
- Define the concepts and terms specific to same-day (rapid) and standard HIV PrEP
- Summarize the descriptive studies on implementation and outcomes of same-day (rapid) oral HIV PrEP
- Differentiate clinic settings best suited to provide same-day (rapid) oral HIV PrEP services
- List the laboratory tests required prior to and the day of prescribing oral HIV PrEP
- Quick ReferenceSame Day (Rapid) Start for Oral HIV PrEP Core Concepts
6Lesson 6 Providing HIV PrEP in Sexual Health Clinic Settings
- Learning Objectives
- Discuss the rationale for providing HIV PrEP services in sexual health clinics based on epidemiology, population served, and sexual health clinic attributes
- Summarize the evidence for the successful integration of HIV PrEP in sexual health clinics, as well as logistical and financial considerations
- Identify HIV PrEP eligibility criteria, screening tools, and partner notification services
- Explain how to optimize HIV PrEP uptake and use via education, outreach, staffing, follow-up, ongoing care, program monitoring
- Describe cost-saving programs for HIV PrEP integration, including 340B eligibility
- Quick ReferenceProviding HIV PrEP in Sexual Health Clinic Settings Core Concepts
- Background
- Rationale for Providing HIV PrEP in Sexual Health Clinics
- Evidence for Providing HIV PrEP in Sexual Health Clinics
- Identifying HIV PrEP Candidates in Sexual Health Clinics
- Identifying and Addressing Barriers in Sexual Health Clinics
- Optimizing Implementation of HIV PrEP in Sexual Health Clinics
- HIV PrEP Follow-Up and Ongoing Care
- Establish and Analyze Clinic HIV PrEP Metrics
- Financial Considerations for PrEP Integration into SHC
- Summary Points
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The National HIV PrEP Curriculum is supported by the Centers for Disease Control and Prevention (CDC) and the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $625,000 from CDC and $300,005 from HRSA with 0% financed with non-governmental sources. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement, by CDC, HRSA, HHS, or the U.S. Government. This project is led by the University of Washington Infectious Diseases Education & Assessment (IDEA) Program.
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